RETRACTED: Cytohesins Are Cytoplasmic ErbB Receptor Activators
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منابع مشابه
RETRACTED: Cytohesins Are Cytoplasmic ErbB Receptor Activators
Signaling by ErbB receptors requires the activation of their cytoplasmic kinase domains, which is initiated by ligand binding to the receptor ectodomains. Cytoplasmic factors contributing to the activation are unknown. Here we identify members of the cytohesin protein family as such factors. Cytohesin inhibition decreased ErbB receptor autophosphorylation and signaling, whereas cytohesin overex...
متن کاملCytohesins Are Cytoplasmic ErbB Receptor Activators
Anke Bill,1,8 Anton Schmitz,1,8 Barbara Albertoni,1 Jin-Na Song,1 Lukas C. Heukamp,2 David Walrafen,3 Franziska Thorwirth,4 Peter J. Verveer,4 Sebastian Zimmer,2 Lisa Meffert,2 Arne Schreiber,3 Sampurna Chatterjee,5 Roman K. Thomas,5,6,7 Roland T. Ullrich,5 Thorsten Lang,3 and Michael Famulok1,* 1LIMES Institute, Program Unit Chemical Biology & Medicinal Chemistry, Laboratory of Chemical Biolog...
متن کاملRetraction Notice to: Cytohesins Are Cytoplasmic ErbB Receptor Activators
(Cell 143, 201–211; October 15, 2010) In Bill et al., we identified the cytohesin ARNO as an ErbB receptor activator that enhances receptor autophosphorylation in H460 and SkBr3 cells. Cell-free reconstitution with purified proteins showed that ARNO enhances EGF receptor autophosphorylation by direct interaction with the intracellular domain of the receptor (EGFR-ICD). Wewere recently notified ...
متن کاملFunction and mode of action of cytohesins in the epidermal growth factor pathway in colorectal cancer cells
Cytohesins have been identified as cytoplasmic ErbB receptor activators in certain cancers, exhibiting an important role in ErbB signaling. However, whether cytohesins are essential in colorectal cancer is unknown. The aim of the present study was to investigate whether cytohesins contribute to the epidermal growth factor (EGF) pathway in colorectal cancer cells. RT-PCR and immunofluorescence e...
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Cytochrome P450 (P450) eicosanoids regulate vascular tone, renal tubular transport, cellular proliferation, and inflammation. Both the CYP4A -hydroxylases, which catalyze 20-hydroxyeicosatetraenoic acid (20-HETE) formation, and soluble epoxide hydrolase (sEH), which catalyzes epoxyeicosatrienoic acid (EET) degradation to the dihydroxyeicosatrienoic acids (DHETs), are induced upon activation of ...
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ژورنال
عنوان ژورنال: Cell
سال: 2010
ISSN: 0092-8674
DOI: 10.1016/j.cell.2010.09.011